Linaclotide is an FDA-approved medication indicated for adults suffering from irritable bowel syndrome with predominant constipation (IBS-C) and chronic idiopathic constipation (CIC). Linaclotide, administered daily, is a potent and highly selective agonist of guanylate cyclase-C (GC-C) receptors in the intestine, offering a novel therapeutic approach with a favorable safety profile. Beyond its FDA-approved indications, linaclotide shows promise in managing refractory lower GI manifestations in systemic sclerosis patients and alleviating constipation induced by various factors such as opioid use, diabetes mellitus, neurological conditions, and post-surgery complications. With IBS-C and CIC affecting approximately 20% of the general population, including the geriatric community, safe and effective long-term prescribed treatments are needed when over-the-counter therapies fail. This activity equips clinicians with the necessary knowledge and skills to identify appropriate candidates for linaclotide therapy, set realistic treatment goals, ensure proper administration and monitoring, and foster collaboration among interprofessional healthcare team members to enhance patient outcomes. This activity describes the indications, mechanism of action, contraindications, adverse event profile, and other key factors pertinent to interprofessional team members when prescribing linaclotide.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/140801
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, All Practice Areas (e.g. ethics), Ambulatory/Outpatient, Bariatric Surgery, Complex General Surgical Oncology, Critical Care Medicine, Endocrinology, Diabetes, and Metabolism, Gastroenterology, General Operative Anesthesia, General Pediatrics, General Surgery, Geriatric Medicine, Hospice & Palliative Medicine, Hospice and Palliative Medicine, Hospital Medicine, Internal Medicine, Medical Toxicology, Neurocritical Care, Pain Medicine, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Gastroenterology, Pediatric Hematology-Oncology, Pediatric Neurology, Pediatric Surgery, Surgical Critical Care, Vascular Surgery