Pentosan polysulfate (PPS) is a commonly used medication to treat interstitial cystitis, also known as bladder pain syndrome. PPS was first associated with a progressive retinal pigmentary maculopathy in 2018, a finding that was later corroborated by several other large studies. PPS maculopathy (PPSM) can cause severe visual impairment by decreasing visual acuity and causing nyctalopia; the condition is generally not reversible and can be progressive. This activity reviews the evaluation, etiology, and diagnostic methodologies to promptly identify PPSM using specialized imaging techniques, shedding light on early recognition and management strategies.As PPS is the only FDA-approved medication for interstitial cystitis, its usage spans beyond this indication, including irritable bowel syndrome and pelvic pain syndrome. This course discussion covers the historical context of PPS, its mechanism of action in urothelial protection, recommended dosages, and its emergence in diverse medical spheres. Considering the evolving understanding of PPSM’s pathophysiology and clinical impact, this activity endeavors to equip healthcare professionals with up-to-date knowledge crucial for recognizing and managing this sight-threatening complication associated with PPS usage in interstitial cystitis and other conditions.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/140250
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 2.0 hours
Nursing: 2.0 hours
Pharmacy: 2.0 hours - MOC Credit Details: ABS - 2.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 2.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 2.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 2.0 Point; Credit Type(s): Self-Assessment (ABS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: All Practice Areas (e.g. ethics), General Surgery, Nephrology