Opioid Antagonists

Opioid Antagonists

Opioid receptor antagonists block one or more of the opioid receptors in the central or peripheral nervous system. Opioid receptors are specific transmembrane neurotransmitter receptors that couple G-proteins, which upon stimulation by endogenous or exogenous opioids, lead to the intracellular process of signal transduction. The two most commonly used centrally acting opioid receptor antagonists are naloxone and naltrexone. Naloxone comes in intravenous, intramuscular, and intranasal formulations and is FDA-approved for use in opioid overdose and the reversal of respiratory depression associated with opioid use. Naltrexone is available in both oral and long-acting injectable formulations and is FDA-approved to treat opioid and/or alcohol maintenance treatment. The most commonly used peripheral opioid receptor antagonist is methylnaltrexone, which is a potent competitive antagonist acting in the digestive tract and is also FDA-approved for the treatment of opioid-induced constipation. This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, monitoring, and toxicity of opioid antagonists, so providers can direct patient therapy to optimal outcomes to combat opioid overdose, misuse, or adverse effects.

  • Provider:StatPearls, LLC
  • Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/26215
  • Start Date: 2023-09-01 05:00:00
  • End Date: 2023-09-01 05:00:00
  • Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
    Nursing: 1.0 hours
    Pharmacy: 1.0 hours
  • MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
    ABOS - 1.0 Point; Credit Type(s): Accredited CME (ABOS)
    ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
    ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
    ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
    ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
    ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
    ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
    ABOHNS - 1.0 Point; Credit Type(s): Self-Assessment (ABOHNS)
    ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS)
    ABIM - 1.0 Point; Credit Type(s): Patient Safety (ABIM)
    ABOHNS - 1.0 Point; Credit Type(s): Patient Safety (ABOHNS)
    ABA - 1.0 Point; Credit Type(s): Patient Safety (ABA)
    ABTS - 1.0 Point; Credit Type(s): Patient Safety (ABTS)
  • Commercial Support: No
  • Activity Type: Enduring Material
  • CME Finder Type: Online Learning
  • Fee to Participate: Variable
  • Measured Outcome: Learner Knowledge, Learner/Team Competence
  • Provider Ship: Directly Provided
  • Registration: Open to all
  • Specialty: Adult Cardiac, Ambulatory/Outpatient, Cardiothoracic, Cardiovascular, Chemical Pathology, Congenital Cardiac, Critical Care, General Operative Anesthesia, General Orthopaedics, General Otolaryngology, General Pediatrics, General Surgery, General Thoracic, Internal Medicine, Non-Thoracic Surgery
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