As a class, nonsteroidal anti-inflammatory drugs, commonly abbreviated as NSAIDs, are chemically varied, yet share similar therapeutic and adverse effects. All drugs within the class work to reduce inflammation, pain, and fever through inhibition of endoperoxide synthesis enzymes, known as cyclooxygenase (COX) enzymes. Both cyclooxygenase isozymes, COX-1 and COX-2, convert arachidonic acid into its endoperoxide metabolites, which include prostacyclin, prostaglandins, and thromboxane; these all have diverse biologic activity, ranging from inflammation, smooth muscle tone, and thrombosis. COX-1 is constitutively expressed and is considered the primary source of prostanoids needed for physiologic homeostases, such as protection of gastric epithelium. COX-2, on the other hand, is inducible, and its production of prostanoids is significantly upregulated during conditions of stress and inflammation. NSAIDs can also result in toxicity by the same pharmacology that makes them so effective therapeutically. This activity reviews the etiology, presentation, evaluation, and management of NSAID toxicity and reviews the role of the interprofessional team in evaluating, diagnosing, and managing the condition.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/30366
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABOS - 1.0 Point; Credit Type(s): Accredited CME (ABOS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABOHNS - 1.0 Point; Credit Type(s): Self-Assessment (ABOHNS)
ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adult Cardiac, Ambulatory/Outpatient, Cardiothoracic, Cardiovascular, Chemical Pathology, Congenital Cardiac, Critical Care, General Operative Anesthesia, General Orthopaedics, General Otolaryngology, General Pediatrics, General Surgery, General Thoracic, Internal Medicine, Medical Toxicology, Non-Thoracic Surgery