Subacute combined degeneration, or combined systems disease, is a neurological complication of vitamin B12 (cobalamin) deficiency. This condition arises from various causes such as nutritional deficiency, altered gastrointestinal anatomy or function, or certain drug intake. Subacute combined degeneration is characterized by demyelination, resulting in degeneration of the spinal cord’s dorsal and lateral columns. Common symptoms include sensory deficits, paresthesia, weakness, ataxia, and gait disturbance. Diagnosis involves assessing macrocytosis, hyper-segmented neutrophils, and mean corpuscular volume, with additional tests like plasma homocysteine and methylmalonic acid levels supporting diagnosis if serum B12 levels are borderline. A thorough neurological examination is also important to institute.In this activity, participants explore the evaluation, treatment, and management of subacute combined degeneration. Initiating prompt treatment to reverse alarming neurological deficits is highlighted, particularly in cases of pernicious anemia. Interprofessional team communication and collaboration in enhancing patient care emphasizes the roles of neurologists, internal medicine specialists, therapists, and other healthcare professionals.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/29600
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Ambulatory/Outpatient, Developmental-Behavioral Pediatrics, Gastroenterology, General Operative Anesthesia, General Pediatrics, General Surgery, Hematology (Blood, BM), Hospital Medicine, Internal Medicine, Neurocritical Care, Neurodevelopmental Disabilities, Neuropathology (incl. Neuromuscular), Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Hematology-Oncology, Pediatric Neurology, Pediatric Rheumatology, Rheumatology