Orlistat (tetrahydrolipstatin) is an anti-obesity medication approved by the US Food and Drug Administration (FDA). This medication is a saturated derivative derived from the endogenous lipstatin found in Streptomyces toxytricini. Orlistat is used to manage obesity by reversibly inhibiting gastric and pancreatic lipases within the gut. These lipases play a crucial role in the digestion of dietary fat by breaking down triglycerides into absorbable free fatty acids and monoglycerides. Orlistat binds covalently to the serine residues of the active sites of these lipases, rendering them inactive. This inactivation of lipase prevents the hydrolysis of triglycerides, thereby impeding the absorption of free fatty acids.The maximum benefit of orlistat is achieved when it is combined with a balanced diet and regular exercise. The off-label use of orlistat includes the treatment of obesity in patients with heart failure, as per the American Heart Association. This activity reviews orlistat’s mechanism of action, adverse events, administration, pharmacodynamics, pharmacokinetics, monitoring strategies, clinical toxicology, and relevant drug interactions related to the care of patients with obesity. This activity also highlights the crucial role of participating clinicians and emphasizes the significance of incorporating dietitians and pharmacists in prescription guidelines to enhance patient outcomes.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/26335
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Adult Cardiac, All Practice Areas (e.g. ethics), Ambulatory/Outpatient, Bariatric Surgery, Cardiothoracic, Cardiovascular, Endocrinology, Diabetes, and Metabolism, General Operative Anesthesia, General Pediatrics, Internal Medicine, Pain Medicine, Pediatric Endocrinology