Amoxicillin-clavulanate is an antibiotic commonly used in emergency departments and primary care offices worldwide. This drug combination offers broader coverage by combining amoxicillin, a penicillin derivative effective against gram-positive and gram-negative bacteria, with clavulanic acid, which counteracts β-lactamase–producing strains. This medication is effective against methicillin-sensitive Staphylococcus aureus (MSSA) and Neisseria species. Indications for amoxicillin-clavulanate administration also include community-acquired pneumonia (CAP), chronic group A streptococci carriers, and small intestinal bacterial overgrowth (SIBO); the efficacy of amoxicillin-clavulanate in treating SIBO approximates 50%. Amoxicillin-clavulanate is also indicated for treating acute bacterial rhinosinusitis; the Infectious Diseases Society of America (IDSA) and the American Academy of Otolaryngology’s Head and Neck Surgery guidelines recommend this combination medication over amoxicillin alone.Healthcare professionals play a critical role in antimicrobial stewardship by prescribing amoxicillin-clavulanate appropriately to prevent resistance. Understanding this drug’s indications, contraindications, and associated adverse reactions aids in optimizing dosage regimens. Monitoring for interactions and understanding clinical toxicology is essential for safe and effective patient care. Familiarity with the pharmacological features of amoxicillin-clavulanate enables informed decision-making, contributing to improved patient outcomes.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/17475
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Dentistry: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABOHNS - 1.5 Point; Credit Type(s): Self-Assessment (ABOHNS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
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- Specialty: Ambulatory/Outpatient, Cardiovascular Disease, Chemical Pathology, Critical Care Medicine, Endocrinology, Diabetes, and Metabolism, General Operative Anesthesia, General Otolaryngology, General Pediatrics, General Surgery, Head & Neck/Oral, Hematology, Hematology (Blood, BM), Hospital Medicine, Infectious Disease, Infectious Diseases/Medical Microbiology, Nephrology, Neurocritical Care, Pediatric Cardiology, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Hematology-Oncology, Pediatric Infectious Diseases, Pediatric Nephrology, Pediatric Pulmonology, Pediatric Transplant Hepatology, Pulmonary Disease, Renal/Medical Renal, Surgical Critical Care, Transplant Hepatology, Trauma