Acute transplant rejection is a condition that occurs within a transplant recipient days to months after transplantation, secondary to the recipient’s immune system identifying the grafted organ as foreign and mounting a defense. The etiology, pathophysiology, presentation, and management of this commonly occurring transplantation complication are complex. The diagnosis of acute rejection is based on clinical features involving the grafted organ and is confirmed by diagnostic laboratory studies, including tissue biopsy. Treatment primarily involves immunosuppressive medications to induce tolerance of alloreactive donor cells and avert rejection. Early diagnosis and intervention of acute transplantation rejection are critical to prevent the loss of donor organs and tissues. The limitations of current risk prediction algorithms and biomarkers have paved the way for understanding the implications of DNA methylation changes in immune pathways, enabling clinicians to tailor personalized prevention and treatment strategies in solid organ transplantation. This activity for healthcare professionals aims to enhance learners’ competence in selecting appropriate diagnostic tests, identifying acute rejection promptly, enabling timely intervention to preserve graft function, minimizing systemic immunosuppression-related adverse effects, and emphasizing the crucial role of the interprofessional team in providing holistic care to affected patients.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/17175
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.0 hours
AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adult Cardiac, Advanced Heart Failure and Transplant Cardiology, Cardiothoracic, Cardiovascular, Critical Care, Critical Care Medicine, Gastroenterology, General Operative Anesthesia, General Pediatrics, General Surgery, General Thoracic, Hospice & Palliative Medicine, Hospice and Palliative Medicine, Hospital Medicine, Internal Medicine, Nephrology, Neurocritical Care, Non-Thoracic Surgery, Pediatric Cardiology, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Gastroenterology, Pediatric Hematology-Oncology, Pediatric Nephrology, Pediatric Pulmonology, Pediatric Transplant Hepatology, Pulmonary Disease, Surgical Critical Care, Transplant Hepatology, Transplant Pathology, Vascular Surgery