While the pharmacokinetics of morphine has been studied extensively, there is only limited study into the pharmacodynamics of morphine for postoperative use in children, The effects of morphine in children after surgery are generally registered using behavior pain scales like the COMFORT-Behavior (COMFORT-B) scale. This scale consists of six behavioral items that quantify pain-associated behavior and symptoms as a proxy for the level of pain, each ranging from 1 (low distress/pain) to 5 (high distress/pain). As such, the total COMFORT-B score ranges from 6 to 30, for which scores of 11 to 16 are clinically aimed for during titration. To quantify the concentration-effect relationship of morphine for postoperative pain in preverbal children between 0 and 3 years of age, we applied Item Response Theory modeling in the pharmacokinetic/pharmacodynamic analysis of COMFORT-B scale data from two previous pediatric clinical studies. Learners that complete this course, will be able to explain the pharmacodynamics of morphine across the pediatric age range.
- Provider:American College of Clinical Pharmacology
- Activity Link: https://www.accp1.org/Members/ACCP1/4Continuing_Education/Virtual_Journal_Club.aspx?hkey=58999de8-6827-42f2-95a0-953fc6102c3a
- Start Date: 2022-08-10 05:00:00
- End Date: 2022-08-10 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
- Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: No, it's free
- Measured Outcome: Learner Competence, Learner Knowledge
- Provider Ship: Directly Provided
- Registration: Open to all