The gut microbiome regulates a number of homeostatic mechanisms in the healthy host including immune function and gut barrier protection. Loss of normal gut microbial structure and function has been associated with diseases as diverse as Clostridioides difficile infection, asthma, and epilepsy. This session will focus on three key areas of the link between the gut microbiome and sepsis. Before sepsis onset, gut microbiome alteration increases sepsis susceptibility through several mechanisms, including allowing for expansion of pathogenic intestinal bacteria, priming the immune system for a robust proinflammatory response, and decreasing production of beneficial microbial products such as short-chain fatty acids. Once sepsis is established, gut microbiome disruption worsens and increases susceptibility to end-organ dysfunction. There is limited evidence that microbiome-based therapeutics, including probiotics and selective digestive decontamination, may decrease sepsis risk and improve sepsis outcomes.
- Provider:Society of Critical Care Medicine
- Activity Link: https://congress2024.sccm.org/aaStatic.asp?SFP=VFJVUUtHWFdAMTU3NjlAQ29uZ3Jlc3MgRGlnaXRhbA
- Start Date: 2024-02-01 06:00:00
- End Date: 2024-02-01 06:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
- MOC Credit Details: ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Competence, Learner Knowledge
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Critical Care Medicine, Pediatric Critical Care Medicine