This activity delves into the pharmacological intricacies of antifungal ergosterol synthesis inhibitors, commonly called “azoles.” These medications, encompassing miconazole, ketoconazole, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, and oteseconazole, play a crucial role in managing diverse fungal infections. The primary mechanism of action involves the inhibition of ergosterol biosynthesis, leading to the disruption of fungal cell membrane integrity. Exploring these azole antifungal agents involves covering indications, contraindications, drug interactions, and adverse event profiles. Notably, the potential for hepatotoxicity necessitates vigilant monitoring and interprofessional communication. These agents’ scientific and medical examination includes in-depth discussions on pharmacokinetics, monitoring protocols, clinical toxicology, and elucidating significant box warnings.By imparting insights into absorption, distribution, metabolism, and elimination, healthcare professionals will be equipped to make informed decisions, ensuring optimal patient outcomes. The emphasis on adverse drug reactions, such as QT interval prolongation and hepatotoxicity, along with a thorough exploration of contraindications, empowers clinicians with the knowledge essential for safe prescribing practices, ultimately enhancing collaborative patient care.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/38859
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABOHNS - 1.5 Point; Credit Type(s): Self-Assessment (ABOHNS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Ambulatory/Outpatient, Critical Care Medicine, General Operative Anesthesia, General Otolaryngology, General Pediatrics, General Surgery, Geriatric Medicine, Hospital Medicine, Infectious Disease, Infectious Diseases/Medical Microbiology, Internal Medicine, Medical Oncology, Medical Toxicology, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Infectious Diseases, Pediatric Otolaryngology, Pediatric Pulmonology, Pulmonary Disease, Surgical Critical Care