In 1943, as the planet was engulfed in WWII and the United States was officially announcing the end of The Great Depression, the most common modern antihistamine, diphenhydramine, was first synthesized. Shortly after, in 1947, orphenadrine was synthesized and used for the treatment of Parkinson disease. With the turn of the decade, antihistamine use became more prevalent, and pediatric deaths increased. A comparison to atropine poisoning and the similar pharmacologic properties between atropine and antihistamines was soon realized. The specific concern of antihistamine toxicity is not due to their competitive H1-receptor binding and sedation but due to their anticholinergic effect. Toxic exposure causes varying degrees of symptoms with differing implications. This activity describes antihistamine toxicity and highlights the role of the interprofessional team in its management.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/30309
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.0 hours
AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABOHNS - 1.0 Point; Credit Type(s): Self-Assessment (ABOHNS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Allergy, Chemical Pathology, Critical Care Medicine, Forensic Pathology, General Operative Anesthesia, General Pediatrics, General Surgery, Geriatric Medicine, Hospital Medicine, Internal Medicine, Medical Toxicology, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Surgical Critical Care