Colesevelam is an FDA-approved antihyperlipidemic drug. When treating hyperlipidemia, colesevelam should be used in conjunction with restriction of cholesterol and fat intake and exercise and can be used as a monotherapy or combined with an HMG-CoA reductase inhibitor ezetimibe, or niacin. It is approved for the treatment of hyperlipidemia from heterozygous familial hypercholesterolemia in adults and as well as in adolescents (10 to 17 years of age) patients. Colesevelam is also indicated to improve glycemic control in adults with type 2 diabetes mellitus along with diet and exercise.
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