Cryoglobulinemia is a rare medical condition characterized by the presence of abnormal proteins called cryoglobulins in the blood, which precipitate or clump together at low temperatures. These cryoglobulins, composed of immunoglobulins and sometimes complement components, deposit in small- to medium-sized blood vessels throughout the body, causing endothelial injury and end-organ damage. Cryoglobulins can cause a range of symptoms, including joint pain, skin rashes, and kidney problems, due to their tendency to obstruct blood vessels and trigger inflammatory reactions.Often associated with underlying diseases such as hepatitis C, autoimmune disorders, or certain cancers, cryoglobulinemia poses a diagnostic and therapeutic challenge due to its varied clinical manifestations. Treatment targets both the cryoglobulins and the underlying conditions, with options including pharmacotherapy, plasmapheresis, and management of associated diseases. Diagnosis involves measuring cryoglobulin levels along with low C4 complement levels. Treatment varies based on the severity and nature of the underlying disorder, with mixed cryoglobulinemia typically treated with steroids and rituximab. This activity focuses on the pathophysiology, clinical manifestations, diagnostic criteria, and management strategies of cryoglobulinemia. This activity also explores current treatment options for cryoglobulinemia, including pharmacological therapies, plasmapheresis, and management of associated conditions. This activity highlights the collaborative role of the interprofessional healthcare team in improving patient care and outcomes for individuals with cryoglobulinemia by providing an in-depth understanding of the condition.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/20147
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.5 hours
AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Cardiovascular, Cardiovascular Disease, General Pediatrics, General Surgery, Hematology, Hematology (Blood, BM), Hospital Medicine, Internal Medicine, Nephrology, Pediatric Cardiology, Pediatric Emergency Medicine, Pediatric Hematology-Oncology, Rheumatology