Doxepin belongs to the class of tricyclic antidepressant medications approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder, anxiety, and insomnia, as well as for managing skin pruritus. Doxepin functions by increasing the concentration of the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) and norepinephrine (NE) in the brain. This mechanism extends the availability of the neurotransmitters (5-HT and NE) within the synaptic cleft and enhances their neurotransmission by preventing their reuptake into the presynaptic terminal.Doxepin also displays antagonistic effects in the central nervous system by blocking receptors such as histamine (H1), α1 adrenergic, and muscarinic. Furthermore, doxepin inhibits sodium and potassium channels in cardiomyocytes, thereby broadening the drug’s indications profile. This activity provides an overview of doxepin’s indications, administration, mechanism of action, adverse effects, contraindications, and toxicity to improve the competence of the interprofessional healthcare team in administering the drug safely and effectively. This activity highlights the importance of utilizing a team-based approach to treat patients with major depressive disorder. Collaborative care involving primary care, psychiatry, and other related disciplines would optimize patient outcomes.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/43596
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Chemical Pathology, General Pediatrics, General Surgery, Hospital Medicine, Internal Medicine, Neuropathology (incl. Neuromuscular), Pain Medicine, Sleep Medicine