Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, belongs to a group of diseases characterized by necrotizing vasculitis affecting small- and medium-sized systemic blood vessels, also known as antineutrophil cytoplasmic autoantibody (ANCA)–associated vasculitis (AAV). EGPA is distinguished from other conditions in this group by its association with asthma, rhinosinusitis, and peripheral eosinophilia. The manifestations of EGPA are typically present in 2 main phenotypes—one characterized by eosinophilic damage and the other by ANCA-associated damage.Although EGPA is classified as an ANCA-associated vasculitis, ANCA is positive in only 30% to 40% of cases, making diagnosis challenging. The dichotomy of presentations and the variability of symptoms make diagnosis particularly challenging. Similarly, treatment responses can be inconsistent, and the recommendations for managing EGPA differ from those for other AAVs, such as granulomatosis with polyangiitis and microscopic polyangiitis. Clinical recognition of multisystem involvement, especially in patients with eosinophilic asthma, is key to diagnosis. The management of EGPA also differs from other AAVs, requiring tailored treatment strategies. This activity reviews the presentation, evaluation, and management of EGPA, highlighting the crucial role of an interprofessional healthcare team in optimizing patient care, particularly given the variability in symptoms and treatment responses.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/19543
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.5 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABOHNS - 1.5 Point; Credit Type(s): Self-Assessment (ABOHNS)
ABTS - 1.5 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Adult Cardiac, Allergy, Ambulatory/Outpatient, Cardiothoracic, Cardiovascular, Cardiovascular Disease, Critical Care, Critical Care Medicine, General Operative Anesthesia, General Otolaryngology, General Pediatrics, General Surgery, Hematology, Hospital Medicine, Internal Medicine, Pediatric Hematology-Oncology, Pediatric Pulmonology, Pediatric Rheumatology, Pulmonary Disease, Pulmonary, Mediastinum, Rheumatology