Factor XIII (FXIII) deficiency is a rare bleeding disorder that presents with symptoms spanning from delayed umbilical cord separation to intracranial hemorrhage. In its activated state, FXIII plays a pivotal role in stabilizing clots and facilitating the cross-linking of the fibrin polymer, thereby ensuring effective hemostasis. Routine coagulation assessments, such as prothrombin time and activated partial thromboplastin time, yield normal results, misleadingly indicating hemostatic normalcy. Individuals with FXIII deficiency may encounter life-threatening bleeding episodes, underscoring the importance of maintaining a heightened level of suspicion.The acquired FXIII deficiency typically arises from factors such as hyperconsumption, hemodilution, and decreased synthesis and is more prevalent than the congenital form. In rare instances, individuals with acquired FXIII deficiency may generate autoantibodies targeting FXIII subunits. Conversely, most patients with the congenital variant display a deficiency in the A subunit. In addition, FXIII is instrumental in various physiological processes such as wound healing, phagocytosis by macrophages, tissue repair, and bacterial immobilization and clearance.Diagnosis involves a stepwise approach, incorporating family history, personal responses to hemostatic challenges, and strategic laboratory testing. Although prophylactic and therapeutic treatment options exist, their limitations may include high cost, limited availability, infection risk, and administration-related complications. This activity discusses the etiology, evaluation, and treatment of FXIII deficiency, emphasizing the pivotal role of the interprofessional healthcare team in identifying and managing this condition.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/21583
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.0 hours
AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Ambulatory/Outpatient, General Operative Anesthesia, General Pediatrics, General Surgery, Hematology, Hematology (Blood, BM), Hematopathology (LN, Spleen), Hemostasis & Thrombosis/Coagulation, Hospital Medicine, Internal Medicine, Molecular Genetic Pathology, Pediatric Hematology-Oncology