Familial hypocalciuric hypercalcemia (FHH) is a genetic condition that occurs as a result of mutations in the calcium-sensing receptor gene leading to decreased receptor activity. FHH is characterized by mild hypercalcemia and is typically found in otherwise healthy and asymptomatic individuals. While most FHH patients remain asymptomatic, those with symptoms may experience fatigue, weakness, constipation, polyuria, polydipsia, or headaches. The hallmark of FHH is an altered calcium-sensing mechanism that makes the parathyroid glands less sensitive to calcium. This requires a higher serum calcium level to suppress parathyroid hormone release, leading to increased calcium and magnesium reabsorption in the kidneys. Parathyroid hormone level is normal or mildly elevated, which can cause FHH to be confused with primary hyperparathyroidism.Diagnostic evaluation usually includes clinical assessment, laboratory studies, and genetic testing. Treatment mainly involves patient education and reassurance, with calcimimetic medications (eg, bisphosphonates) used in more symptomatic cases, despite not being FDA-approved for FHH. This activity for healthcare professionals is designed to enhance the learner’s competence in familial hypocalciuric hypercalcemia diagnosis and implementation of an appropriate interprofessional approach when managing this condition.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/21613
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Endocrine, Endocrinology, Diabetes, and Metabolism, General Pediatrics, General Surgery, Internal Medicine, Molecular Genetic Pathology, Pediatric Endocrinology