Fanconi anemia is the most common cause of inherited bone marrow failure due to a rare autosomal recessive genetic disorder involving all 3 blood cell lines in which homozygous or heterozygous mutations result in pathogenic alleles, including point mutations, duplications, splicing defects, and deletions. These genetic mutations of Fanconi anemia genes cause an accruement of chromosomal damage due to the cell’s inability to conduct repairs. These genetic mutations in the Fanconi anemia pathway lead to cells that cannot properly repair DNA damage, resulting in genomic instability, subsequent pancytopenia, and an increased susceptibility to cytotoxic agents, ultraviolet radiation, spontaneous deformation, and predisposition to malignancies. Additionally, Fanconi anemia affects almost all organs of the body.Fanconi anemia is also thought of as an inherited form of aplastic anemia. The disorder may also predispose patients to the development of hematologic and solid tumors. A Fanconi anemia diagnosis is typically confirmed with a chromosomal fragility test, which remains the gold standard. Management of Fanconi anemia primarily includes supportive therapy, hematopoeitic stem cell transplantation, and androgen treatment. This activity for healthcare professionals aims to enhance learners’ competence in selecting appropriate diagnostic tests, managing Fanconi anemia, and fostering effective interprofessional teamwork to improve outcomes.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/17534
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABOS - 1.5 Point; Credit Type(s): Accredited CME (ABOS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Adult Reconstruction, Critical Care Medicine, Foot and Ankle, General Orthopaedics, General Pediatrics, General Surgery, Hematology, Hematology (Blood, BM), Hematopathology (LN, Spleen), Hemostasis & Thrombosis/Coagulation, Hospital Medicine, Internal Medicine, Molecular Genetic Pathology, Musculoskeletal Oncology, Neonatal-Perinatal Medicine, Pediatric Anesthesia, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Hematology-Oncology, Pediatric Orthopaedic Surgery, Shoulder and Elbow, Soft Tissue & Bone, Surgery of the Hand