Gamma-Hydroxybutyrate Toxicity

Gamma-Hydroxybutyrate Toxicity

Gamma hydroxybutyrate (GHB) is pharmaceutically manufactured as sodium oxybate for the treatment of narcolepsy. This formulation is considered a Schedule III drug in the United States and is sometimes abused. In Europe, GHB is also still therapeutically used as an anesthetic and for the treatment of alcohol and opiate dependence. Since there is no specific antidote to reverse the toxicity, aggressive supportive care including mechanical ventilation may be required. Severe withdrawal symptoms are life threatening and can last up to 15 days. Patients should be treated with benzodiazepines and managed in the intensive care unit. Parents and guardians should be educated about safe storage of this agent to prevent accidental poisoning in children. This activity outlines the potential for abuse of this drug, reviews treatment for patients who have overdosed on it, and identifies the role of the interprofessional team in improving outcomes for patients that use gamma hydroxybutyrate.

  • Provider:StatPearls, LLC
  • Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/315
  • Start Date: 2023-09-01 05:00:00
  • End Date: 2023-09-01 05:00:00
  • Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
    Nursing: 1.0 hours
    Pharmacy: 1.0 hours
  • MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
    ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
    ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
    ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
    ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
    ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
  • Commercial Support: No
  • Activity Type: Enduring Material
  • CME Finder Type: Online Learning
  • Fee to Participate: Variable
  • Measured Outcome: Learner Knowledge, Learner/Team Competence
  • Provider Ship: Directly Provided
  • Registration: Open to all
  • Specialty: Adolescent Medicine, Chemical Pathology, Critical Care Medicine, Forensic Pathology, General Pediatrics, General Surgery, Hospital Medicine, Internal Medicine, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Sleep Medicine
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