Graham-Little-Piccardi-Lasseur syndrome (GLPLS) is a rare variant of lichen planopilaris—a follicular form of lichen planus. Alongside frontal fibrosing alopecia and classic lichen planopilaris, GLPLS is 1 of 3 variants of lichen planopilaris. The etiology of GLPLS remains uncertain, but it is believed to involve a T-cell–mediated autoimmune mechanism. GLPLS symptoms typically begin with the appearance of hyperkeratotic papules on the trunk and extremities before alopecia develops. The syndrome is characterized by multifocal, patchy, cicatricial alopecia on the scalp, noncicatricial alopecia in the axillae and perineum, and follicular hyperkeratosis on the trunk and extremities.Diagnosis relies on clinical presentation, histopathological analysis, and the exclusion of similar conditions. Treatment focuses on interrupting disease progression, relieving symptoms, and enhancing cosmesis through various modalities, including topical and systemic medications, surgical interventions, and patient support. Interventions must be tailored to each patient’s needs and monitored for efficacy and safety. This activity reviews the histology, etiology, diagnosis, and management of GLPLS, as well as highlights the critical role of the interprofessional healthcare team in evaluating and treating this condition. This activity allows clinicians to treat GLPLS through tailored interventions by implementing appropriate treatment modalities and ensuring ongoing monitoring by an interprofessional healthcare team, which is crucial for improving patient care, prognosis, and quality of life.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/22386
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Dermatopathology, General Surgery, Internal Medicine, Molecular Genetic Pathology