IgA pemphigus, an uncommon autoimmune blistering skin disorder, manifests as painful, itchy blisters that fill with neutrophils and evolve into pustules. This condition encompasses 2 clinically similar subtypes: subcorneal pustular dermatosis and intraepidermal neutrophilic dermatosis. Both subtypes exhibit distinct immunologic mechanisms targeting keratinocyte cell surface components. Diagnosis and subtype determination rely on histopathology and immunofluorescence findings. Despite typically presenting a less severe course than IgG-driven pemphigus, precise diagnosis and aggressive treatment with steroids and dapsone are imperative to avert relapses. Given the potential association with underlying malignancies or rheumatological and gastrointestinal disorders, a thorough physical examination and pertinent testing are essential for comprehensive patient evaluation.This activity reviews a better understanding of IgA pemphigus, its clinical nuances, and the latest evidence-based management strategies. In addition, the interplay between circulating IgA antibodies and specific keratinocyte cell surface autoantigens is discussed. By empowering healthcare professionals with valuable insights and tools, this activity aims to optimize patient care for this complex and rare condition, thereby enhancing their competence in managing IgA pemphigus effectively.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/26886
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Chemical Pathology, Dermatopathology, Gastroenterology, General Pediatrics, General Surgery, Infectious Disease, Internal Medicine, Molecular Genetic Pathology, Pediatric Gastroenterology, Pediatric Hematology-Oncology, Pediatric Infectious Diseases, Pediatric Rheumatology, Rheumatology