Toll like receptor (TLR) and nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR)-containing proteins (NLR) proteins form sensors on our immune cells to detect pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs). TLR receptors when activated prime the NLRP3 receptors. NLRP3 receptors when activated trigger the production of inflammasomes and subsequent cell death by pyroptosis. Both of these receptors and their pathways are important in creation and maintenance of inflammation. However, in subclinical/chronic inflammation these pathways can become potentially dysregulated. In this talk we will present an overview of these pathways, their interaction with each other and the possible ways to modulate these pathways. Objectives: 1. Quick review of the key inflammatory pathways. 2. TLR pathway overview. 3. How TLR pathway primes NLRP3 pathway. 4. NLRP3 pathway and its function for inflammasomal activity. 5. What are inflammasomes? 6. Studies demonstrating micronutrients that can modulate these pathways. 7. Role of hydroxychloroquine while modulating these pathways.
- Provider:DrBeen Corp
- Activity Link: https://members.drbeen.com/library/inflammatory-pathways-tlr-and-nlrp-pathways-modulation-inflammation-part-2/ry2WRPEPA
- Start Date: 2024-07-10 05:00:00
- End Date: 2024-07-10 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 0.75 hours
- Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Yes
- Measured Outcome: Learner Competence
- Provider Ship: Directly Provided
- Registration: Open to all