Isoniazid (INH) is a potent bactericidal antibiotic prescribed for tuberculosis (TB). Treatment with INH therapy has a risk of toxicity, which is acute or chronic, leading to long-term liver damage if not appropriately treated. Acute toxicity manifests as neurological symptoms, often in the form of seizures refractory to benzodiazepines. Chronic toxicity usually presents as hepatotoxicity and peripheral neuropathy. The toxicity may easily present in the full spectrum of medical settings, though less likely in emergency departments, if pyridoxine is prescribed with INH from therapy initiation. With increasing INH prescriptions for TB, cases of INH toxicity may rise due to dosage errors. Management includes discontinuing INH, administering pyridoxine for acute toxicity, considering liver support therapies if hepatic damage occurs, and occasionally resorting to liver transplants.Throughout this activity, participants explore the spectrum of INH toxicity presentations, learning to recognize key features and differentiate them from other drug toxicities. Emphasis is placed on early intervention strategies, including administering pyridoxine for acute toxicity and appropriate management of chronic hepatotoxicity. Moreover, this course underscores the importance of an interprofessional approach in managing INH toxicity, highlighting the collaborative efforts of clinicians across specialties. By participating in this course, clinicians enhance their competence in recognizing, diagnosing, and managing INH toxicity, ultimately improving patient outcomes and ensuring safe prescribing practices in TB treatment.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/23787
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Ambulatory/Outpatient, Chemical Pathology, Critical Care Medicine, Forensic Pathology, Gastroenterology, General Operative Anesthesia, General Pediatrics, General Surgery, Geriatric Medicine, Hospital Medicine, Infectious Disease, Internal Medicine, Medical Toxicology, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Gastroenterology, Pediatric Infectious Diseases, Pediatric Neurology, Pediatric Pulmonology, Pulmonary Disease