Misoprostol is exclusively approved by the US Food and Drug Administration (FDA) for the prevention and treatment of gastric ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are taking NSAIDs and are at high risk for ulceration. Misoprostol has 4 primary effects, including cytoprotection of the gastrointestinal mucosa, uterotonic properties, diarrhea, and abdominal pain, with the latter 2 considered adverse effects. Misoprostol is indicated, although not FDA-approved, for short-term treatment of active duodenal or gastric ulcers caused by other factors. Despite its global use in gynecology and obstetrics, none of these applications are FDA-approved. The regulatory landscape in the United States has changed since 2022, following the overturn of Roe v. Wade, with state-to-state regulations evolving.The combination of misoprostol and mifepristone is FDA-approved for medical abortions, offering a highly effective option with an acceptable safety profile. In instances where mifepristone is unavailable, a misoprostol-only regimen is the recommended alternative. This activity will emphasize the mechanism of action, adverse event profile, pharmacokinetics, monitoring, and relevant interactions of misoprostol, which are essential for interprofessional team members treating patients with conditions warranting its use. This activity helps clinicians gain insight into the optimal utilization of misoprostol, particularly in collaborative efforts to address gastrointestinal, obstetric, and gynecological issues.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/25188
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.5 hours
AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: All Practice Areas (e.g. ethics), Gastroenterology, General Surgery, Internal Medicine