Myeloperoxidase (MPO) is a hemoprotein expressed in azurophilic granules of neutrophils and in the lysosomes of monocytes. The enzyme has strong antibacterial properties and is unique in its ability to generate potent bactericidal compounds such as hypochlorous acid (HOCl) from hydrogen peroxide and the halide, chloride. Myeloperoxidase deficiency, first described in 1954 is an autosomal recessive disorder caused by mutations in the MPO gene on chromosome 17. It is the commonest inherited defect of phagocytes. Patients with MPO deficiency have impaired microbial killing, but the majority are asymptomatic clinically except if they are also diabetic. This activity presents the cause, pathophysiology, clinical presentation and diagnosis of MPO deficiency and highlights the role of the interprofessional team in the management of these patients.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/25452
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: General Pediatrics, General Surgery, Hematology (Blood, BM), Infectious Disease, Internal Medicine, Molecular Genetic Pathology, Pediatric Infectious Diseases