Nitrosoureas are medications used to manage and treat high-grade gliomas and glioblastomas, as well as some lung tumors, pancreatic islet cell tumors, Hodgkin’s disease, non-Hodgkin’s lymphomas, and melanomas. They are classified as alkylating agents with high lipophilicity, and they treat brain cancers effectively. There is no known antidote for nitrosourea toxicity, and treatment involves drug cessation, supportive care, and, when indicated transfusions. Close monitoring for toxicity is necessary for patients on nitrosourea therapy.This course reviews the acute and subacute toxicity of some of the most commonly used nitrosoureas. Nitrosoureas have a severe and extensive side effect profile that can cause considerable toxicity in therapeutic doses. Some of the known side effects of nitrosourea toxicity are pulmonary fibrosis leading to hypoxia and dose-dependent myelosuppression. Apparent histopathological features narrow the differential diagnosis considerably, though toxic effects are exerted on several organ systems. Participating clinicians will learn how to work within an interdisciplinary team in identifying, evaluating, and treating patients with nitrosourea toxicity. In particular, the approach to identifying the toxic signs of an emergency versus long-term exposure is reviewed.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/148523
- Start Date: 2024-12-01 06:00:00
- End Date: 2024-12-01 06:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Advanced Heart Failure and Transplant Cardiology, Ambulatory/Outpatient, Cardiovascular Disease, Chemical Pathology, Complex General Surgical Oncology, Critical Care Medicine, Forensic Pathology, Gastroenterology, General Operative Anesthesia, General Surgery, Hematology, Hematology (Blood, BM), Hospice & Palliative Medicine, Hospice and Palliative Medicine, Hospital Medicine, Internal Medicine, Medical Oncology, Medical Toxicology, Nephrology, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Nephrology, Pediatric Neurology, Pediatric Pulmonology, Pulmonary Disease, Pulmonary, Mediastinum