Organophosphates encompass a diverse group of chemical compounds with common applications in pesticides and herbicides, as well as nerve agents in chemical warfare. When introduced into the body, organophosphates inhibit the enzyme acetylcholinesterase, resulting in an overabundance of the neurotransmitter acetylcholine. This surplus of acetylcholine in the body manifests with cholinergic toxidrome, which includes effects on nicotinic and muscarinic receptors, as well as the central nervous system. Respiratory failure resulting from bronchorrhea and bronchospasm is the leading cause of death in cases of organophosphate toxicity. Chronic toxicity and neurological complications, such as the intermediate syndrome, are also well documented. Although developed nations have experienced a decline in poisoning cases due to stricter regulations on the use of these chemicals, developing countries still face a clinical concern, especially when these chemicals are used for self-harm purposes. Antidotal therapy and comprehensive supportive care from healthcare professionals are necessary for the effective treatment of organophosphate toxicity to prevent morbidity and mortality. This activity reviews the assessment and treatment of organophosphate toxicity while highlighting the role of the interprofessional healthcare team in recognizing organophosphate toxicity and treating patients with this condition.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/30370
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.5 hours
AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Ambulatory/Outpatient, Chemical Pathology, Critical Care Medicine, Forensic Pathology, General Operative Anesthesia, General Pediatrics, Hospital Medicine, Internal Medicine, Medical Toxicology, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pulmonary Disease, Surgical Critical Care