Prothrombin complex concentrate (PCC) comes from the process of ion-exchange chromatography from the cryoprecipitate supernatant of large plasma pools and after removal of antithrombin and factor XI. This agent’s initial development was for hemophilia; however, with the availability of recombinant replacement factors, it no longer has a use in this setting. It is now used to replace congenital or acquired vitamin-K deficiency warfarin-induced anticoagulant effect, particularly in the emergent setting. The FDA-approved indication is for urgent reversal of acquired coagulation factor deficiency induced by warfarin-induced anticoagulation in patients presenting with major acute bleeding (intracerebral hemorrhage-ICH) or needing urgent invasive surgery or procedure. This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, monitoring, and toxicity of prothrombin complex concentrate, so providers can direct patient therapy in treating conditions for which it is indicated, as part of the interprofessional team.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/27891
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABOS - 1.5 Point; Credit Type(s): Accredited CME (ABOS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.5 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABOHNS - 1.5 Point; Credit Type(s): Self-Assessment (ABOHNS)
ABTS - 1.5 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adult Cardiac, Ambulatory/Outpatient, Bariatric Surgery, Cardiothoracic, Cardiovascular, Cardiovascular Disease, Clinical Cardiac Electrophysiology, Complex General Surgical Oncology, Congenital Cardiac, Critical Care, Critical Care Medicine, General Operative Anesthesia, General Orthopaedics, General Otolaryngology, General Pediatrics, General Surgery, General Thoracic, Hematology, Hemostasis & Thrombosis/Coagulation, Hospital Medicine, Internal Medicine, Interventional Cardiology, Medical Toxicology, Neuro Anesthesia, Neurocritical Care, Non-Thoracic Surgery, Orthopaedic Trauma, Pediatric Cardiology, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Hematology-Oncology, Pediatric Neurology, Pediatric Surgery, Pulmonary Disease, Surgical Critical Care, Trauma, Vascular Surgery