This activity focuses on small interfering RNA (siRNA) therapy, exemplified by FDA-approved agents such as patisiran, givosiran, lumasiran, inclisiran, nedosiran, and vutrisiran. These therapies are pivotal in managing rare metabolic ailments, including hereditary transthyretin amyloidosis (hATTR), acute hepatic porphyria (AHP), primary hyperoxaluria type 1 (PH1), and lowering low-density lipoprotein cholesterol (LDL-C) in subjects with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD). The activity will discuss the mechanism of action of siRNA, its adverse event profile, and other key factors essential for interprofessional team members involved in patient care. Furthermore, participants will gain insights into administration techniques, contraindications, clinical toxicology, and monitoring strategies necessary to safely and effectively utilize siRNA therapies in clinical practice.Understanding the intricate pharmacology of siRNA is crucial for healthcare professionals to deliver precise therapeutic interventions in various clinical scenarios. This activity equips participants with comprehensive knowledge encompassing the mechanism of action, potential adverse reactions, and contraindications, empowering them to integrate advanced therapeutic strategies into patient care. This comprehension ensures that professionals possess the requisite expertise to provide optimal and innovative patient care within the dynamic realm of medical science, thereby enhancing patient outcomes and contributing to the advancement of medical practice.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/143337
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, Adult Cardiac, Adult Congenital Heart Disease, All Practice Areas (e.g. ethics), Cardiothoracic, Cardiovascular, Cardiovascular Disease, Endocrinology, Diabetes, and Metabolism, General Pediatrics, General Surgery, Hematology, Hospital Medicine, Internal Medicine, Interventional Cardiology, Medical Toxicology, Nephrology, Pediatric Cardiology, Pediatric Endocrinology, Pediatric Nephrology, Pediatric Pulmonology, Pulmonary Disease