Stroke reperfusion injury refers to the exacerbation of cellular dysfunction and death upon restoration of blood flow to previously ischemic brain tissues following an ischemic stroke. Stroke represents a significant global burden, contributing substantially to both mortality and disability, with an estimated prevalence of approximately 2.5%. Disruption of the blood supply to the brain by either a thrombus or an embolus leads to an ischemic stroke. Ischemia-reperfusion injury, characterized by the temporary restriction and subsequent restoration of blood supply to tissues, presents a significant challenge in clinical practice.While reperfusion aims to alleviate tissue hypoxia and salvage ischemic tissues, it paradoxically exacerbates tissue damage, impeding organ function and viability. This phenomenon, observed across various organs, including the brain, involves intricate molecular and cellular mechanisms leading to extensive tissue destruction not only in global hypoxic injury but also in focal ischemic injury such as stroke. This activity underscores the significance of understanding the pathophysiological mechanisms driving reperfusion injury, their clinical implications, and the emerging neuroprotective strategies to mitigate ischemia-reperfusion injury to develop effective strategies for healthcare providers to optimize clinical outcomes. This activity also emphasizes the role of an interprofessional healthcare team in delivering comprehensive care for affected patients through the integration of evidence-based approaches to minimize reperfusion injury while maximizing the benefits of reperfusion therapies.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/28384
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.0 hours
AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Critical Care Medicine, General Operative Anesthesia, General Pediatrics, Hospital Medicine, Internal Medicine, Neuro Anesthesia, Neurocritical Care, Neuropathology (incl. Neuromuscular), Pediatric Emergency Medicine, Pediatric Neurology, Pulmonary Disease