T-PLL (T Prolymphocytic leukemia) is a mature and aggressive T-cell leukemias characterized by the proliferation of small to medium-sized prolymphocytes that show mature or post-thymic T cell phenotype. T-PLL involves peripheral blood (PB), bone marrow (BM), lymph nodes, liver, spleen, and skin. The name “prolymphocyte” is inaccurate, as the tumor cells in this disease are of post-thymic T cell in origin. T-PLL increases in ataxia-telangiectasia (ATM) patients. Whole-genome sequencing and whole-exome sequencing have demonstrated mutations in the following genes: IL2RG, JAK1, JAK3, STAT5B, EZH2, FBXW10, and CHEK2. This activity reviews the evaluation of T cell prolymphocytic leukemia and identifies the role of the interprofessional team in managing this condition.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/50561
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABOS - 1.0 Point; Credit Type(s): Accredited CME (ABOS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Ambulatory/Outpatient, Critical Care Medicine, Cytopathology, General Operative Anesthesia, General Orthopaedics, Geriatric Medicine, Hematology, Hematology (Blood, BM), Hematopathology (LN, Spleen), Hospice & Palliative Medicine, Hospice and Palliative Medicine, Hospital Medicine, Internal Medicine, Medical Oncology, Molecular Genetic Pathology, Musculoskeletal Oncology