Tissue plasminogen activator (tPA) is classified as a serine protease (enzymes that cleave peptide bonds in proteins). It is thus one of the essential components of the dissolution of blood clots. Its primary function includes catalyzing the conversion of plasminogen to plasmin, the primary enzyme involved in dissolving blood clots. Examples of these drugs include alteplase, reteplase, and tenecteplase. Indications for the use of tPA include ischemic stroke (most common) in patients presenting to treating facility within 3 hours (4.5 hours in certain, eligible patients) after the onset of symptoms, myocardial Infarction if there would be a delay of more than 1 to 2 hours before percutaneous transluminal coronary angioplasty, pulmonary embolism in massive pulmonary embolisms, causing severe instability due to high pressure on the heart, and thrombolysis (e.g., deep vein thrombosis). This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, toxicity, and monitoring, of tPA agents so providers can direct patient therapy where they are indicated as part of the interprofessional team.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/30217
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.5 hours
Nursing: 1.5 hours
Pharmacy: 1.5 hours - MOC Credit Details: ABS - 1.5 Point; Credit Type(s): Accredited CME (ABS)
ABOS - 1.5 Point; Credit Type(s): Accredited CME (ABOS)
ABPATH - 1.5 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.5 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.5 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.5 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.5 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.5 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABTS - 1.5 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adult Cardiac, Adult Congenital Heart Disease, Advanced Heart Failure and Transplant Cardiology, Ambulatory/Outpatient, Cardiac Anesthesia, Cardiothoracic, Cardiovascular, Cardiovascular Disease, Clinical Pathology, Critical Care, Critical Care Medicine, General Operative Anesthesia, General Orthopaedics, General Pediatrics, General Surgery, General Thoracic, Geriatric Medicine, Hematology, Hemostasis & Thrombosis/Coagulation, Hospital Medicine, Internal Medicine, Interventional Cardiology, Medical Oncology, Medical Toxicology, Neuro Anesthesia, Neurocritical Care, Non-Thoracic Surgery, Pediatric Cardiology, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Neurology, Pediatric Pulmonology, Pulmonary Disease, Surgical Critical Care