This activity offers an in-depth examination of upadacitinib, a second-generation selective Janus kinase (JAK) inhibitor targeting the JAK1 enzyme, approved by the FDA for treating various chronic inflammatory conditions such as moderate to severe rheumatoid arthritis (RA), psoriatic arthritis, atopic dermatitis, ankylosing spondylitis, Crohn disease, and ulcerative colitis. The session will cover the specific mechanism by which upadacitinib inhibits key intracellular cytoplasmic enzymes (Janus kinases) involved in immune-mediated inflammatory diseases, disrupting the JAK-STAT signaling pathway and thereby reducing inflammatory responses.This educational initiative is designed to update healthcare professionals on the critical aspects of upadacitinib, including its adverse event profile and other essential considerations for patient management. The program will provide comprehensive insights into clinical strategies for integrating upadacitinib into treatment regimes, focusing on dosage optimization and adverse reaction mitigation to enhance patient care outcomes. By the end of this discussion, participants will be equipped with the necessary evidence-based knowledge to effectively administer upadacitinib in clinical settings.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/135218
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABOS - 1.0 Point; Credit Type(s): Accredited CME (ABOS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, All Practice Areas (e.g. ethics), Ambulatory/Outpatient, Gastroenterology, General Orthopaedics, General Pediatrics, General Surgery, Internal Medicine, Medical Toxicology, Pain Medicine, Pediatric Gastroenterology, Pediatric Rheumatology, Rheumatology