Uremia is a clinical condition associated with declining renal function and is characterized by fluid overload, electrolyte imbalances, metabolic abnormalities, and physiological changes. The term “uremia” literally means “urine in the blood,” which develops most commonly in chronic and end-stage renal disease. However, less commonly, this condition can also manifest in acute kidney injury if kidney function deteriorates rapidly. Urea exhibits direct and indirect toxicity to various tissues, notably affecting the neurological system. Urea acts as a marker for uremic toxins in general, with over 100 substances identified as potential uremic toxins, which are present in varying concentrations in the blood. Urea and other uremic toxins, accumulated due to impaired renal clearance, are toxic to various tissues, especially the nervous system, leading to symptoms such as nausea, vomiting, fatigue, anorexia, muscle cramps, pruritus, and altered mentation. These manifestations significantly diminish a patient’s quality of life and, if left untreated, can result in morbidity and mortality.Due to the frequent occurrence of altered mental status in patients, early recognition by healthcare professionals is crucial for promptly initiating renal replacement therapy and potential renal transplant referral, leading to improved patient outcomes. Healthcare professionals must also vigilantly monitor for any signs of uremia to prevent associated complications. Timely referral to transplantation centers is associated with improved survival rates and reduced morbidity among uremia patients. This activity reviews the evaluation and management of uremia, emphasizing the collaborative role of interprofessional team members in delivering well-coordinated care to improve outcomes for affected patients.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/30806
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.0 hours
AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Chemical Pathology, Clinical Pathology, Critical Care, Critical Care Medicine, Endocrinology, Diabetes, and Metabolism, General Pediatrics, Hospital Medicine, Internal Medicine, Nephrology, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Endocrinology, Pediatric Nephrology, Pediatric Rheumatology, Rheumatology, Surgical Critical Care