Uremic encephalopathy is a cerebral dysfunction caused by the accumulation of toxins due to acute or chronic renal failure. This condition typically develops in patients with acute or chronic renal failure whose estimated glomerular filtration rate is below 15 mL/min. The clinical presentation varies widely, from subtle to florid, and the clinical course invariably progresses if left untreated. The syndrome likely results from alterations in hormonal metabolism, retention of uremic solutes, changes in electrolyte and acid-base homeostasis, blood-brain barrier transport, vascular reactivity issues, and inflammation. Urea is the most commonly measured indicator of uremic toxins, but many other substances are being studied as contributors to uremia.Diagnosis of uremic encephalopathy is challenging because there are no specific clinical, laboratory, or imaging findings. The condition is often diagnosed retrospectively when symptoms improve after dialysis or kidney transplantation. If symptoms do not improve after clearing toxic solutes, other potential causes should be investigated. Early recognition and treatment are crucial, as uremic encephalopathy is an absolute indication for initiating renal replacement therapy. Management also includes addressing chronic kidney disease with treatments such as erythropoiesis-stimulating agents, phosphate binders, calcium supplements, and nutritional modifications. This activity emphasizes the evaluation and treatment of uremic encephalopathy, emphasizing the role of the interprofessional team in patient care.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/91332
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: IPCE Credits: 1.0 hours
AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
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- Specialty: Adolescent Medicine, Chemical Pathology, Clinical Pathology, Critical Care, Critical Care Medicine, General Pediatrics, Geriatric Medicine, Hospital Medicine, Internal Medicine, Nephrology, Neurocritical Care, Pediatric Critical Care Medicine, Pediatric Emergency Medicine, Pediatric Nephrology, Pediatric Neurology, Surgical Critical Care