Vancomycin flushing syndrome (VFS), previously known as red man syndrome, is an anaphylactoid reaction caused by the rapid infusion of the glycopeptide antibiotic vancomycin. VFS consists of a pruritic, erythematous rash of the face, neck, and upper torso, which may also involve the extremities, though to a lesser degree. Symptoms may include weakness, angioedema, and chest or back pain. VFS is caused by vancomycin through the direct and non-immune-mediated histamine release from mast cells and basophils. The amount of histamine released is generally related to the dosage of vancomycin infused and the infusion rate. VFS is generally associated with more rapid infusion rates but can be seen following slower infusion rates and after several days of transfusion. Practitioners using vancomycin should be aware of this drug reaction, its prevention, and treatment. This activity describes the evaluation, diagnosis, and management of vancomycin flushing syndrome and stresses the role of team-based interprofessional care for affected patients.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/28290
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
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ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
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- Activity Type: Enduring Material
- CME Finder Type: Online Learning
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- Specialty: Adult Cardiac, Ambulatory/Outpatient, Cardiothoracic, Cardiovascular, Clinical Pathology, Congenital Cardiac, Critical Care, Critical Care Medicine, General Operative Anesthesia, General Orthopaedics, General Otolaryngology, General Pediatrics, General Surgery, General Thoracic, Internal Medicine, Neurocritical Care, Non-Thoracic Surgery