Vinca alkaloids, a cell cycle phase M-specific anti-tubulin agent class, have been pivotal in cancer treatment since their early development. Derived from the periwinkle plant (Catharanthus roseus), these alkaloids include first-generation (vincristine, vinblastine), second-generation semi-synthetic derivatives (vinorelbine, vindesine), and the latest addition, vinflunine—known for fluorinated, anti-microtubule properties. Vinflunine stands out with enhanced potency and reduced adverse events, particularly in the context of treating transitional cell urothelial bladder cancer. These medications pose challenges, as toxicity spans multiple organ systems, predominantly manifesting as neurotoxicity, and necessitates vigilance in therapeutic dosing to avoid adverse events, especially with vincristine.Participants explore the spectrum of vinca alkaloid toxicity, focusing on early recognition and management of adverse effects. Updated insights into dose adjustments, patient-specific risk factors, and tailored interventions are discussed. The role of the interprofessional team, including oncologists, nurses, pharmacists, and therapists, in comprehensive patient care is emphasized. By fostering interdisciplinary collaboration, clinicians enhance patient safety through early detection, tailored interventions, and optimized treatment strategies. Engagement in this course empowers healthcare professionals to recognize and manage vinca alkaloid toxicity effectively. This course ensures clinicians are equipped with the latest knowledge and skills to navigate the complexities of vinca alkaloid therapy, ultimately improving patient care and outcomes in cancer treatment.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/273
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABA - 1.0 Point; Credit Type(s): Lifelong Learning (ABA)
ABTS - 1.0 Point; Credit Type(s): Accredited CME (ABTS)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP)
ABTS - 1.0 Point; Credit Type(s): Self-Assessment (ABTS) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Ambulatory/Outpatient, Cardiothoracic, Chemical Pathology, Complex General Surgical Oncology, Gastroenterology, General Operative Anesthesia, General Pediatrics, Hematology, Hospital Medicine, Internal Medicine, Medical Oncology, Medical Toxicology, Pediatric Emergency Medicine, Pediatric Hematology-Oncology