Voclosporin, a novel immunosuppressive medication, is approved for treating and managing lupus nephritis (LN) within the class of calcineurin inhibitors (CNIs). LN is a common manifestation of systemic lupus erythematosus (SLE), an autoimmune disease affecting various organs. Approximately 40% of SLE patients may develop LN. The primary goal of LN treatment is to preserve kidney function, reduce mortality, and improve the patient’s quality of life while minimizing treatment-related adverse events. A timely response to therapy, as indicated by a reduction in proteinuria, may predict long-term outcomes, including the risk of SLE flares, end-stage kidney disease, and mortality. In the United States, voclosporin received FDA approval in 2021 for treating active LN in adults, combined with background immunosuppressive therapy. This CME activity overviews the indications, actions, and contraindications for voclosporin. It also emphasizes the mechanism of action, adverse event profile, and key factors such as dosing, pharmacokinetics, contraindications, and monitoring that are essential for healthcare team members involved in treating patients with lupus nephritis using voclosporin.
- Provider:StatPearls, LLC
- Activity Link: https://www.statpearls.com/ArticleLibrary/viewarticle/155737
- Start Date: 2023-09-01 05:00:00
- End Date: 2023-09-01 05:00:00
- Credit Details: AMA PRA Category 1 Credit™️: 1.0 hours
Nursing: 1.0 hours
Pharmacy: 1.0 hours - MOC Credit Details: ABS - 1.0 Point; Credit Type(s): Accredited CME (ABS)
ABPATH - 1.0 Point; Credit Type(s): Lifelong Learning (ABPATH)
ABIM - 1.0 Point; Credit Type(s): Medical Knowledge (ABIM)
ABS - 1.0 Point; Credit Type(s): Self-Assessment (ABS)
ABP - 1.0 Point; Credit Type(s): Lifelong Learning and Self-Assessment (ABP) - Commercial Support: No
- Activity Type: Enduring Material
- CME Finder Type: Online Learning
- Fee to Participate: Variable
- Measured Outcome: Learner Knowledge, Learner/Team Competence
- Provider Ship: Directly Provided
- Registration: Open to all
- Specialty: Adolescent Medicine, All Practice Areas (e.g. ethics), General Pediatrics, General Surgery, Hospital Medicine, Internal Medicine, Nephrology, Pediatric Nephrology, Pediatric Rheumatology, Rheumatology